Biology

Swapping Birth and Death: Symmetries and Transformations in Phylodynamic Models

Abstract

Stochastic birth–death models provide the foundation for studying and simulating evolutionary trees in phylodynamics. A curious feature of such models is that they exhibit fundamental symmetries when the birth and death rates are interchanged. In this article, we first provide intuitive reasons for these known transformational symmetries. We then show that these transformational symmetries (encoded in algebraic identities) are preserved even when individuals at the present are sampled with some probability. However, these extended symmetries require the death rate parameter to sometimes take a negative value. In the last part of this article, we describe the relevance of these transformations and their application to computational phylodynamics, particularly to maximum likelihood and Bayesian inference methods, as well as to model selection.

Source link




Related posts

Complementing neutralization of viruses by antibodies

Newsemia

Gap perception in bumblebees [RESEARCH ARTICLE]

Newsemia

Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism

Newsemia

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More

Privacy & Cookies Policy