Biology

Postdoctoral position in Mouse Embryonic Development and Stem Cell Biology

We offer one fully-funded postdoctoral position up to five years in the Laboratory of Genome Integrity located at the National Institutes of Health (NHI/NCI, Bethesda, MD).

 

Our laboratory uses human and mouse embryonic stem cells (ESCs) as well as mouse embryos to understand the molecular mechanisms underlying the maintenance/exit of pluripotency and self-renewal. Understanding cell plasticity, pluripotency and differentiation to get a better comprehension of embryonic development, cell transformation and cancer are our scientific interests.

 

The applicant should have or about to have a PhD in Developmental Biology, Genetics or similar, and should have demonstrated expertise on molecular biology/mammalian tissue culture. Knowledge in mouse embryology, computational biology and next generation sequencing technologies will be considered as an advantage.

 

We seek a highly motivated, creative individual, eager to learn and develop new technologies and complex cell systems based on live cell/embryo imaging, single-cell technologies, 3D modelling and CRISPR-based editing interested in understanding how a single cell can develop into a complex multicellular organism in vitro and in vivo.

 

Please send a brief cover letter, CV and three reference letters via e-mail to:

 

sergio.ruizmacias@nih.gov

https://ccr.cancer.gov/Laboratory-of-Genome-Integrity/sergio-ruiz-macias

 

  • Mayor-Ruiz C, et al. ERF deletion rescues RAS deficiency in mouse embryonic stem cells. Genes & Dev. 32: 568-576, 2018.
  • Olbrich T, et al. A p53-dependent response limits the viability of mammalian haploid cells. Proc Natl Acad Sci U S A. 114: 9367-9372, 2017.
  • Ruiz S, et al. A genome-wide CRISPR screen identifies CDC25A as a determinant of sensitivity to ATR inhibitors. Mol Cell. 62: 307-13, 2016.
  • Ruiz S, et al. Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells. Nature Commun. 6: 8036, 2015.
  • Ruiz S, et al. Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 109: 17196-201, 2012

The post Postdoctoral position in Mouse Embryonic Development and Stem Cell Biology appeared first on the Node.

Source link




Related posts

Lower extremity joints and muscle groups in the human locomotor system alter mechanical functions to meet task demand [RESEARCH ARTICLE]

Newsemia

Correction: Single-cell selectivity and functional architecture of human lateral occipital complex

Newsemia

A fitness cost resulting from Hamiltonella defensa infection is associated with altered probing and feeding behaviour in Rhopalosiphum padi [RESEARCH ARTICLE]

Newsemia

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More

Privacy & Cookies Policy