Gastroenterology

Rare inheritable form of NAFLD driven by gene mutation

Researchers identified monoallelic ABHD5 mutations as a driver of inheritable nonalcoholic fatty liver disease that manifests after age 40 years, according to data published in Journal of Hepatology.
“The existence of inherited forms of NAFLD has been suspected, but neither a specific causal gene or a susceptibility locus has been identified,” Leila Youssefian, MSc, from Thomas Jefferson University in Philadelphia, Pennsylvania, and colleagues wrote. “The specific metabolic and cellular mechanism(s) leading to NAFLD are still under investigation, but there is strong evidence

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