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Influence of insulin resistance illustrates heightened CVD risk in ‘pre-prediabetes’

PHILADELPHIA — Insulin resistance is a more important cardiometabolic risk factor than glucose tolerance, increasing cardiovascular risk even before hyperglycemia increases risk for diabetes, according to a speaker at the third annual Heart in Diabetes conference.
“I’m not really a believer that hyperglycemia is a major risk factor in developing cardiovascular disease, and the problem starts long before you develop diabetes,” Ralph A. DeFronzo, MD, director of the diabetes research unit at the University of Texas Health Science Center at San Antonio, said during the

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