Neurology

Author response: ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS

We thank Raaphorst et al. for the comment on our article.1We acknowledged the possible role of respiratory functioning in both the discussion and analysis of data without stage 4 patients; however, 27.78% (n = 15) of stage 4 patients in this study were on noninvasive ventilation (NIV) at the time of testing for at least 2 weeks. No substantial differences were found in any cognitive or behavioral domain between NIV and non-NIV stage 4 patients.

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