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Cardiovascular risk factors and arterial thrombotic events in congenital heart disease patients.

Int J Clin Pract. 2019 May 29;:e13378

Authors: Martínez-Quintana E, Rodríguez-Hernández JL, Rodríguez-González F, Riaño-Ruiz M, Fraguela-Medina C, Girolimetti A, Jiménez-Rodríguez S

Abstract
INTRODUCTION: As congenital patients get older it can be hypothesized that cardiovascular risk factors increase.
METHODS: Retrospective study of congenital heart disease (CHD) patients attended between January 2008 and September 2018. Cardiovascular risk factors, myocardial infarction, stroke, peripheral vascular disease and analytical data such as serum glucose and lipid profile were determined.
RESULTS: 818 CHD patients and 1955 control patients matched for age and sex were studied. CHD patients were distributed in simple (462 patients), moderate (228 patients) and great (128 patients) complexity. CHD patients were significantly more hypertensive and diabetic but less dyslipidemic and smokers than patients in the control group. 27 (3.3%) CHD patients had an arterial thrombotic event: 3 coronary, 22 neurological and 2 peripheral vascular disease. No significant differences were seen in the incidence of myocardial infarction between the control and the CHD groups. However CHD patients had a significant higher incidence of arterial thrombotic events (coronary, neurological and peripheral vascular events) at the expense of strokes and transient ischemic attacks (22 vs. 2 events in CHD and control patients, respectively). Also, no significant differences were seen in age, sex, BMI, arterial hypertension, diabetes mellitus, dyslipidemia, smoking habit, serum glucose, total and LDL cholesterol, statin treatment, myocardial infarction and arterial thrombotic events according to CHD complexity. Being older and having arterial hypertension, diabetes mellitus, dyslipidemia and smoking habit were more frequent among CHD patients with arterial thrombosis.
CONCLUSIONS: CHD are more hypertensive and diabetic but less dyslipemic and smokers than patients in the control group. CHD patients have a higher incidence of neurological events but not of myocardial infarction in relation to the control population. This article is protected by copyright. All rights reserved.

PMID: 31141298 [PubMed – as supplied by publisher]

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