Tissue-dependent variations of hydrogen sulfide homeostasis in anoxic freshwater turtles [SHORT COMMUNICATION]

Birgitte Jensen, Sibile Pardue, Christopher G. Kevil, and Angela Fago

Hydrogen sulfide (H2S) controls numerous physiological responses. To understand its proposed role in metabolic suppression, we measured free H2S and bound sulfane sulfur (BSS) in tissues of the freshwater turtle Trachemys scripta, a species undergoing strong metabolic suppression when cold and anoxic. In warm normoxic turtles, free H2S was higher in red blood cells (RBCs) and kidney (~9-10 µmol l–1) compared to brain, liver and lung (~1-2 µmol l–1). These values overall aligned with the tissue H2S-generating enzymatic activity. BSS levels were similar in all tissues (~0.5 µmol l–1) but ~100-fold higher in RBCs, having a high thiol content, suggesting that RBCs function as a circulating H2S reservoir. Cold-acclimation caused significant changes in free and bound H2S in liver, brain and RBCs, but anoxia had no further effect, except for the brain. These results show tissue-dependent sulfide signaling with a potential role in brain metabolic suppression during anoxia in turtles.

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