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Prophylactic cranial irradiation decreases incidence of brain metastasis in NSCLC

Prophylactic cranial irradiation improved DFS and decreased brain metastasis rates at 5 and 10 years compared with observation among patients with stage III locally advanced non-small cell lung cancer, according to results of a randomized phase 3 trial published in JAMA Oncology.
The treatment, however, did not improve OS, the study’s primary outcome. But, researchers noted that the reason for this result could be poor patient accrual. The original aim was to enroll 1,058 participants, but total accrual at study closing was only 356, including 16 patients who were deemed ineligible or

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