Multiple sclerosis (MS) is a progressive neurologic disease, which usually affects younger individuals and causes significant permanent disability. It is believed that pathophysiology of MS possesses two arms: inflammatory demyelination and neurodegeneration with resultant brain and spinal cord tissue atrophy due to significant tissue loss. In the past two decades, the role of central nervous system (CNS) tissue atrophy has been emerging as a significant marker of disability in MS patients and substantial research efforts have been focused on the gray matter as well as white matter volume loss in the context of the neurodegenerative arm of this progressive neurologic disease.

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