Neurology

Author response: Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline

We thank Dr. Young for his insightful comment. While there is a biologically plausible mechanism by which orthostatic hypotension (OH) may affect cognition, we agree that our results also support the idea that OH may operate primarily through vascular processes and may simply be a biomarker of elevated vascular risk; this is supported by our results that OH appeared detrimental in persons with hypertension and diabetes, as noted in the Discussion.1

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