We appreciate the interest in our study on late-life blood pressure (BP) and postmortem neuropathology in nearly 1,300 community-dwelling, autopsied persons.1 While we chose to separately examine longitudinal systolic BP (SBP) and diastolic BP (DBP) data, and indeed found more robust associations of a higher mean and more rapidly declining SBP with neuropathology, we agree that examining other BP variables provides additional insight into this area of research. Using the same datasets and a similar analytic approach of adjusted ordinal regression analyses, we found consistent results using additional BP variables. Increased variability in SBP over the years (p = 0.002), but not variability in DBP (p = 0.945), was associated with increased odds of brain infarcts, and increased mean pulse pressure over the years increased the odds of infarcts by 24% (p < 0.001). In adjusted linear regression analyses, there was no relation of variability in SBP or DBP with neurofibrillary tangles (both p > 0.574), and there was a borderline association of increased mean pulse pressure with a higher number of tangles (p = 0.084). Ongoing research will further elucidate the complex relationship of cardiovascular disease with brain dysfunction,2,3 including whether specific neuropathologies mediate the relation of BP to dementia in aging.
You may also like
Reply to the letter entitled “Predictors of respiratory impairment in patients with myotonic dystrophy type 1”
- May 26, 2019
We read with interest the letterRead more
Study discovers origin of neurofibromas that develop throughout the skin of NF1 patients
- May 26, 2019
A study published today in PLOSRead more