More evidence for high-sensitivity troponin assays

Symptoms suggestive of myocardial infarction (MI) represent one of the most common conditions in patients presenting to the emergency department. For the diagnostic evaluation of these patients, algorithms based on cardiac troponin are recommended by guidelines and used in daily practice worldwide.1 In the past 10 years, substantial improvements of these diagnostic strategies have been achieved. This is mainly based on a higher assay sensitivity, which allows the detection of very low troponin concentrations with a high accuracy.2 Using low cut-off concentrations, rapid strategies for rule out of MI after 3 hour or only 1 hour are feasible, efficient and safe. Even a single baseline rule out using a very low troponin cut-off concentration, measured by a high-sensitivity troponin (hs-Tn) assay, provides a high safety to rule out MI.3–6 Currently, up to 20 different troponin assays are commercially available.2 This...

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