A watch-and-wait strategy for certain patients with rectal cancer who achieved clinical complete response following neoadjuvant therapy yielded high rates of rectal preservation and pelvic tumor control, according to a recent study published in JAMA Oncology.
 However, the approach appeared associated with shorter survival and higher incidence of distant progression among patients with local regrowth.
“Our group previously noted that a watch-and-wait approach was safe and efficacious after clinical complete response; however, the intervals of follow-up were short and the numbers of

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