Neurology

Neurofilament light chain: An important step toward a disease biomarker in multiple sclerosis

Multiple sclerosis (MS) is a chronic progressive disorder of the CNS that leads to neurodegeneration and accumulation of neurologic disability. At disease onset, it is challenging to predict whether individual patients will have a benign or aggressive disease course, and whether individual patients will respond to disease-modifying therapies. MS phenotypes1 and diagnostic criteria2 are defined on the basis of clinical and MRI characteristics. They are limited in their ability to guide treatment decisions.

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