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A semi-supervised deep learning method based on stacked sparse auto-encoder for cancer prediction using RNA-seq data.

Comput Methods Programs Biomed. 2018 Nov;166:99-105

Authors: Xiao Y, Wu J, Lin Z, Zhao X

BACKGROUND AND OBJECTIVE: Cancer has become a complex health problem due to its high mortality. Over the past few decades, with the rapid development of the high-throughput sequencing technology and the application of various machine learning methods, remarkable progress in cancer research has been made based on gene expression data. At the same time, a growing amount of high-dimensional data has been generated, such as RNA-seq data, which calls for superior machine learning methods able to deal with mass data effectively in order to make accurate treatment decision.
METHODS: In this paper, we present a semi-supervised deep learning strategy, the stacked sparse auto-encoder (SSAE) based classification, for cancer prediction using RNA-seq data. The proposed SSAE based method employs the greedy layer-wise pre-training and a sparsity penalty term to help capture and extract important information from the high-dimensional data and then classify the samples.
RESULTS: We tested the proposed SSAE model on three public RNA-seq data sets of three types of cancers and compared the prediction performance with several commonly-used classification methods. The results indicate that our approach outperforms the other methods for all the three cancer data sets in various metrics.
CONCLUSIONS: The proposed SSAE based semi-supervised deep learning model shows its promising ability to process high-dimensional gene expression data and is proved to be effective and accurate for cancer prediction.

PMID: 30415723 [PubMed – indexed for MEDLINE]

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