Cooling Down the Hot Potato: Anti-Interleukin 36 Therapy Prevents and Treats Experimental Intestinal Fibrosis

The majority of patients with Crohn’s disease (CD) experience fibrosis associated complications over their lifetime culminating in need for resection.1 Increasing evidence suggests that fibrosis is also common and clinically relevant in the colon of patients with ulcerative colitis, with clinical implications such as urgency or diarrhea.2 Intestinal fibrosis represents perhaps the most significant remaining challenge in the field of inflammatory bowel diseases (IBD) because specific antifibrotic therapies are currently not available.

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