Patients with Crohn’s disease (CD) suffer from abnormally high rates of depression and anxiety. Depression among patients with CD are higher than other debilitating chronic medical conditions, such as cancer. Behavioral co-morbidities are associated with increased rates of flares, more severe disease course, and increased rate of corticosteroid prescription. Psychological stress, even among CD patients in remission, is recognized as a risk factor for flare-ups. Despite the well-established relationship between stress and symptom relapse, a rigorous mechanistic explanation remains elusive.

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