Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin

Saccharopine, a nonproteinogenic amino acid originally isolated from the yeast Saccharomyces cerevisiae, is an intermediate in lysine metabolism. In this issue, Zhou et al. (2019. J. Cell Biol. show that abnormal accumulation of saccharopine results in defective mitochondrial dynamics and function in worm and mouse models.

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