Postdoctoral position in Mouse Embryonic Development and Stem Cell Biology

We offer one fully-funded postdoctoral position up to five years in the Laboratory of Genome Integrity located at the main campus of the National Institutes of Health (NIH/NCI, Bethesda, MD).Our laboratory uses human and mouse embryonic stem cells (ESCs) as well as mouse embryos to understand the molecular mechanisms underlying the maintenance/exit of pluripotency and self-renewal. Understanding cell plasticity, pluripotency and differentiation to get a better comprehension of embryonic development, cell transformation and cancer are our scientific interests.

Areas of Expertise:

1) Embryonic stem cells 2) Embryology 3) Pluripotency 4) Somatic cell reprogramming 5) CRISPR-based screenings 6) Differentiation 7) Cell plasticity 8) DNA damage.

The applicant should have or about to have a PhD in Developmental Biology, Genetics or similar, and must have demonstrated expertise in mouse embryology and in vitro embryo manipulation. Knowledge on mammalian tissue culture, molecular biology and/or next generation sequencing technologies and computational biology will be considered as an advantage. The applicant will have the opportunity to develop his/her research program or lead ongoing projects.

We seek a highly motivated, interactive, creative individual, eager to learn and develop new technologies and complex cell systems based on live cell/embryo imaging, 3D modelling and CRISPR-based editing interested in understanding how a single cell can develop into a complex multicellular organism in vitro and in vivo.


Please send a brief cover letter, CV and at least two reference letters via e-mail to:


Sergio Ruiz Macias (NIH/NCI) [E]

Laboratory of Genome Integrity

Center for Cancer Research

National Cancer Institute, NIH

Building 37, Room 1108

Bethesda, Maryland 20892

Further information about our lab and publications can be found at:

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