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Complete genome sequence of Achromobacter insolitus type strain LMG 6003T, a pathogen isolated from leg wound.



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Complete genome sequence of Achromobacter insolitus type strain LMG 6003T, a pathogen isolated from leg wound.

Pathog Dis. 2017 06 01;75(4):

Authors: Li G, Zhang T, Yang L, Cao Y, Guo X, Qin J, Yang Q, You S, Yuan G, Jiang K, Luo J, Li Z, Gao L, Jiang K, Wu L, Zheng J

Abstract
Achromobacter insolitus is a newly described, Gram-negative, small (1-2 mm long) and coccoid pathogen that has been isolated from leg wound. Due to its potential threat to human beings, the type strain of this species LMG 6003T was completely sequenced in this study. The genomic analysis revealed that the genome of LMG 6003T consists of one circular DNA chromosome of 6 492 697 bp with a GC content of 65.10%. The entire genome contains 6208 predicted coding genes, 61 tRNAs and 13 rRNA genes. Comparative genome analysis between LMG 6003T and another selected 10 sequenced Achromobacter revealed that 725 genes only exist in LMG 6003T. In particular, these genes include several important pathogenic-related genes such as Type IV prepilin peptidase (TadV/CpaA), Type VI secretion lipoprotein (VasD) and type 1 fimbriae major subunit (FimA). Genomic island (GI) analysis also suggests the existence of GIs in LMG 6003T. All these results strongly suggest the unique genomic features in LMG 6003T against other Achromobacter species. This report will provide us with an extended understanding of A. insolitus at the genomic level and would be helpful for understanding the evolution of the Achromobacter genus.

PMID: 28369432 [PubMed – indexed for MEDLINE]

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