In “Increased resting cerebral blood flow in adult Fabry disease: MRI arterial spin labeling study,” Phyu et al. reported that patients with Fabry disease (FD) have significantly higher cerebral blood flow (CBF) in the white matter than normal controls, and that this difference is most notable in the splenium of the corpus callosum (SCC). Based on these findings, they proposed that white matter hyperintensities (WMH) in patients with FD are the result of hyperperfusion.

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