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Eliminating microglia prevents heightened immune sensitivity after stress




Using an animal model of chronic stress, researchers at The Ohio State University have shown that the immune cells of the brain, called microglia, hold unique signatures of chronic stress that leave the animal more sensitive to future stressful experiences, evident by increased anxiety and immune responses. Eliminating microglia so that these “stress memories” could not be maintained did not prevent the increased anxiety in response to later stress but did prevent the hypersensitive immune response.

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