Gastroenterology

Modeling Human Digestive Diseases with CRISPR-Cas9-modified Organoids




Insights into the stem cell niche have allowed researchers to cultivate adult tissue stem cells as organoids that display structural and phenotypic features of healthy and diseased epithelial tissues. Organoids derived from patients’ tissues are used as models of disease and to test drugs. CRISPR-Cas9 technology can be used to genetically engineer organoids for studies of monogenic diseases and cancer. We review the derivation of organoids from human gastrointestinal tissues and how CRISPR-Cas9 technology can be used to study these organoids.

Source link




Related posts

Functional GI Circle IBS Webinar Series Recordings

Newsemia

CMS Approves GIQuIC as a Qualified Clinical Data Registry for the 2017 Reporting Year

Newsemia

Research recommends prompt endoscopic removal when children swallow button batteries

Newsemia

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More

Privacy & Cookies Policy