Teaching NeuroImages: Morphology of lumbosacral dorsal root ganglia and plexus in hereditary transthyretin amyloidosis

A 66-year-old man presented with a 5-year history of progressive distal dominant sensorimotor disturbance, which suggested length-dependent polyneuropathy. 3D magnetic resonance neurography (3D-MRN) showed enlargement of the dorsal root ganglia and the lumbosacral plexus (figure). The diagnosis of hereditary transthyretin (ATTRm) amyloidosis was based on genetic and histopathologic findings.

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