Modulating apical-basal polarity by building and deconstructing a Yurt

Cell polarity is regulated by protein networks in the apical and basolateral domains that repress one another by mutually antagonistic interactions. Gamblin et al. (2018. J. Cell Biol. reveal that apical Crumbs is antagonized by oligomerization of basolateral Yurt, while Yurt oligomerization is in turn negatively regulated by the apical kinase aPKC.

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