Neurology

Neuromyelitis optica spectrum disorders (NMO-SD) in a Sub-Saharan Africa country: A preliminary study of sixteen Senegalese cases.





Neuromyelitis optica spectrum disorders (NMO-SD) in a Sub-Saharan Africa country: A preliminary study of sixteen Senegalese cases.

Mult Scler Relat Disord. 2018 Oct 26;27:179-183

Authors: Gaye NM, Fall M, Diop AM, Dadah SML, Ka M, Cissé O, Diagne NS, Diop-Sène MS, Sow AD, Basse-Faye AM, Sarr MM, Touré K, Seck LB, Ndiaye M, Diop AG

Abstract
BACKGROUND: Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system. In Sub-Saharan Africa, publications are rare and deal with isolated cases. Our goal was to analyze the characteristics of NMO spectrum disorders in a Senegalese cohort compiled in Dakar.
PATIENTS AND METHOD: This was a retrospective descriptive study conducted at the Neurology Department of Fann Teaching Hospital. We included all patients with NMO-SD according to the 2014 diagnostic criteria.
RESULTS: Sixteen patients were enrolled, 4 men and 12 women with an average age of 30 years. Ten patients (62.5%) presented an acute myelopathy associated with retrobulbar optic neuritis and 5 (31.25%) had isolated spinal cord injury. Spinal MRI showed abnormal cervical (6 patients), dorsal (4 patients), bulbar-cervical (3 patients) or cervico-dorsal (2 patients) signal extended (≥3 vertebral segments) of the spinal cord. Visual evoked potentials (VEP) showed demyelinating optic nerve involvement in 8 patients. Ten patients were positive to AQP-4 IgG. Systemic corticosteroid therapy was the rule in all patients, associated with azathioprine in 10 of them. The clinical course at 3 months was predominantly favourable (10 patients).
CONCLUSION: This cohort is the first one compiled in Dakar. African multicentric epidemiological studies are needed.

PMID: 30388487 [PubMed – as supplied by publisher]

Source link




Related posts

Predictors for Epilepsy Following Acute Symptomatic Neonatal Seizures Remain Elusive

Newsemia

Molecular Link Discovered Between Aging and ALS, Dementia

Newsemia

Disability Blogger Award (x2!)

Newsemia

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More

Privacy & Cookies Policy