The Impact of Earlier Intervention by an Antimicrobial Stewardship Team for Specific Antimicrobials in a Single Weekly Intervention.
Int J Infect Dis. 2018 Oct 04;:
Authors: Hagiwara D, Sato K, Miyazaki M, Kamada M, Moriwaki N, Nakano T, Shiotsuka S, Tokushige C, Toh H, Kamimura H, Togawa A, Takata T
OBJECTIVE: The objective of this study is to evaluate the effects of earlier intervention by an antimicrobial stewardship team (AST) on antimicrobial use, antimicrobial resistance rates, and the clinical outcomes, without changing the weekly intervention schedule.
METHODS: A retrospective study was conducted at Fukuoka University Hospital between April 2013 and March 2016. The effects were compared among three study periods (SP): SP1 (patients receiving anti-MRSA agents and carbapenems for ≥14 days), SP2 (patients receiving specific antimicrobials for ≥14 days), and SP3 (patients receiving specific antimicrobials regardless of the duration of treatment).
RESULTS: The timing of AST intervention shortened from an average of 15.5days after administration in SP1 to 4.2days in SP3. The antimicrobial use density (AUD) of carbapenems and piperacillin-tazobactam decreased significantly (SP2 vs. SP3, p <0.05), and the costs of specific antimicrobials decreased (SP1, US$ 1,080,000; SP2, US$ 944,000; and SP3, US$ 763,000). The rates of carbapenem resistance among P. aeruginosa isolates showed a significant reduction from 16.2% in SP2 to 8.7% in SP3 (p<0.05). The mortality rate and length of stay did not change during the study period.
CONCLUSIONS: Earlier intervention by an AST could contribute to the proper use of antimicrobials without adversely affecting patient outcomes.
PMID: 30292892 [PubMed – as supplied by publisher]