Neurology

Autoimmune encephalitis with elevated N-type calcium channel antibodies as a multiple sclerosis mimic.

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Autoimmune encephalitis with elevated N-type calcium channel antibodies as a multiple sclerosis mimic.

Mult Scler Relat Disord. 2018 Sep 25;26:201-203

Authors: Frey J, Murray A

Abstract
BACKGROUND: Voltage gated calcium channels (VGCC) are well-known targets for antibody-associated disease. Of the 5 VGCC subtypes, the most well-known is the P/Q subtype associated with Lambert-Eaton Myasthenic Syndrome (LEMS). However, this case focuses on the much less understood N-type calcium channel antibody. The objective of this case is to review the literature regarding the clinical significance of the N-type calcium channel antibody and its relationship to MS.
METHODS: A 37-year old male presented with vertigo, paranoia, and tremor and had MRI changes suggestive of demyelinating disease. Evaluation revealed positive N-type calcium channel antibodies. Steroids dramatically improved symptoms and normalized antibodies. Years later recurrent symptoms were again associated with elevated antibodies.
RESULTS AND CONCLUSION: This patient likely has autoimmune encephalitis associated with elevated N-type calcium channel antibodies. This case highlights the clinical significance of N-type calcium channel antibodies and the importance of correctly diagnosing patients with antibody mediated disease that may very well mimic more common neurologic diseases such as multiple sclerosis (MS).

PMID: 30268041 [PubMed – as supplied by publisher]

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