AMP-activated protein kinase sparks the fire of cardioprotection against myocardial ischemia and cardiac ageing.
Ageing Res Rev. 2018 Aug 12;:
Authors: Gu C, Li T, Jiang S, Yang Z, Lv J, Yi W, Yang Y, Fang M
AMP-activated protein kinase (AMPK) is a pivotal regulator of some endogenous defensive molecules in various pathological processes, particularly myocardial ischemia (MI), a high risk of myocardial infarction. Thereby it is of great significance to explore the inherent mechanism between AMPK and myocardial infarction. In this review, we first introduce the structure and role of AMPK in the heart. Next, we introduce the mechanisms of AMPK in the heart; followed by the energy regulation of AMPK in MI. Lastly, the attention will be expanded to some potential directions and further perspectives. The information compiled here will be helpful for further research and drug design in the future before AMPK might be considered as a therapeutic target of MI.
PMID: 30110651 [PubMed – as supplied by publisher]