Dermatology

Ipilimumab for the treatment of advanced melanoma in six kidney transplant patients.

Related Articles

Ipilimumab for the treatment of advanced melanoma in six kidney transplant patients.

Am J Transplant. 2018 Aug 14;:

Authors: Zehou O, Leibler C, Arnault JP, Sayegh J, Montaudié H, Rémy P, Glotz D, Cordonnier C, Martin L, Lebbé C

Abstract
Immune checkpoint inhibitors are new therapeutic options for metastatic melanoma, but little data is available in organ transplant recipient populations. Six French patients, 3 men and 3 women, mean age 66 years (range 44-74), all kidney transplant recipients, received ipilimumab (CTLA-4 inhibitor) for metastatic melanoma. At diagnosis of advanced melanoma, immunosuppressive therapy had been minimized in all but one. Adverse effects included one case of grade 1 diarrhea and one grade 1 pruritus. One patient had acute T-cell-mediated rejection confirmed by histology, after the first injection of ipilimumab. After a median follow-up of 4.5 (3-20) months, one patient achieved partial response, one had stable disease and four had disease progression. All the patients died, 5 from melanoma, 1 from another cause. In this series and in the literature, ipilimumab proves to be safe and possibly active. The acute rejection we encountered was probably related to both a rapid, drastic reduction of immunosuppression and to the use of ipilimumab. Our safety data on ipilimumab contrasts with the organ transplant rejections already reported with PD-1 inhibitors. We consider that immunosuppression should not be minimized, as the impact on metastatic disease control is probably small. This article is protected by copyright. All rights reserved.

PMID: 30107088 [PubMed – as supplied by publisher]

Source link




Related posts

Clinical characteristics, culprit drugs and outcome of patients with Acute Generalised Exanthematous Pustulosis seen in Hospital Sultanah Aminah, Johor Bahru.

Newsemia

How to Spoil Your Dad With Spa Treatments

Newsemia

Large Nasal Defects with Exposed Cartilage: The Folded Transposition Flap as an Innovative Alternative to the Paramedian Forehead Flap.

Newsemia

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More

Privacy & Cookies Policy