Biology

An in vivo test of the biologically relevant roles of carotenoids as antioxidants in animals [SHORT COMMUNICATION]

Ryan J. Weaver, Philip Wang, Geoffrey E. Hill, and Paul A. Cobine

Carotenoids are well known for their contribution to the vibrant coloration of many animals and have been hypothesized to be important antioxidants. Surprisingly few examples of carotenoids acting as biologically relevant antioxidants in vivo exist, in part because experimental designs often employ dosing animals with carotenoids at levels that are rarely observed in nature. Here we use an approach that reduces carotenoid content from wild-type levels to test for the effect of carotenoids as protectants against an oxidative challenge. We used the marine copepod, Tigriopus californicus reared on a carotenoid-free or a carotenoid-restored diet of nutritional yeast and then exposed them to a prooxidant. We found that carotenoid-deficient copepods not only accumulated more damage, but also were more likely to die during an oxidative challenge than carotenoid-restored copepods. We suggest that carotenoid reduction, and not supplementation, better tests the proposed roles of carotenoids in other physiological functions in animals.

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