Gastroenterology

Simvastatin Prevents Progression of Acute on Chronic Liver Failure in Rats With Cirrhosis and Portal Hypertension

Cirrhosis and its clinical consequences can be aggravated by bacterial infections, ultimately leading to the development of acute on chronic liver failure (ACLF), characterized by acute decompensation, organ failure, and high mortality within 28 days. Little is known about cellular and molecular mechanisms of ACLF in patients with cirrhosis, so no therapeutic options are available. We developed a sepsis-associated pre-clinical model of ACLF to facilitate studies of pathogenesis and evaluate the protective effects of simvastatin.

Source link




Related posts

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

Newsemia

Telehealth for Nutritional Interventions – Opportunities for Innovation and Improved Care

Newsemia

Less than one-third of reproductive-age women with rheumatic disease use prescription contraception

Newsemia

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More

Privacy & Cookies Policy